| WEST JEFFERSON Seed: 14 2 |
| Date: 10/19/2021 Time: 6:00 PM |
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25-18, 25-14, 25-27, 21-25, 15-3
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| GRANDVIEW HTS. Seed: 8 3 |
| MILFORD CENTER FAIRBANKS Seed: 7 3 |
| Date: 10/19/2021 Time: 6:00 PM |
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25-23, 24-26, 25-19, 16-25, 15-9
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| CENTERBURG Seed: 9 2 |
| CARDINGTON-LINCOLN Seed: 2 3 |
| Date: 10/19/2021 Time: 6:00 PM |
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25-22, 25-21, 25-11
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| RICHWOOD NORTH UNION Seed: 16 0 |
| JOHNSTOWN NORTHRIDGE Seed: 1 3 |
| Date: 10/23/2021 Time: 2:30 PM |
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25-10, 25-17, 25-17
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| GRANDVIEW HTS. Seed: 8 0 |
| MOUNT GILEAD Seed: 15 2 |
| Date: 10/23/2021 Time: 2:30 PM |
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24-26, 24-26, 25-23, 25-22, 15-11
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| AMANDA-CLEARCREEK Seed: 17 3 |
| COLS. AFRICENTRIC Seed: 18 0 |
| Date: 10/23/2021 Time: 2:30 PM |
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25-10, 25-10, 25-10
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| MILFORD CENTER FAIRBANKS Seed: 7 3 |
| COLS. MARION-FRANKLIN Seed: 19 0 |
| Date: 10/23/2021 Time: 2:30 PM |
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25-7, 25-3, 25-9
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| CARDINGTON-LINCOLN Seed: 2 3 |
| JOHNSTOWN NORTHRIDGE Seed: 1 3 |
| Date: 10/28/2021 Time: 6:00 PM |
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25-7, 25-14, 25-12
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| AMANDA-CLEARCREEK Seed: 17 0 |
| MILFORD CENTER FAIRBANKS Seed: 7 0 |
| Date: 10/28/2021 Time: 7:30 PM |
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25-9, 25-23, 25-23
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| CARDINGTON-LINCOLN Seed: 2 3 |
| JOHNSTOWN NORTHRIDGE Seed: 1 1 |
| Date: 10/30/2021 Time: 7:30 PM |
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25-22, 25-21, 13-25, 25-22
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| CARDINGTON-LINCOLN Seed: 2 3 |
| CARDINGTON-LINCOLN |
| Mt. Vernon 2 District Champion | | to Regional Tournament | | vs. Clayton 2 District winner | | Thu., Nov 4 - as visiting team |
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